Fig. 4.

(A and B) Heatmaps depicting communities of significantly targeted GO terms (FDR < 0.001, ES > 0.65) based on GSEA analyses on all possible miRNA/tissue pairs for the networks modeled on the TargetScan (A) and the miRanda (B) prior. (C) Similarity (measured with Jaccard index) of miRNA/tissue–GO term associations in the subset of communities that target at least five GO terms identified in networks modeled using the TargetScan or miRanda prior. Each community is labeled with a number from 1 to 9 and prefix ‘C’. (D) Word clouds depicting communities targeting at least five GO terms. Community pairs with the highest Jaccard index are shown. We omitted TargetScan community 8 and miRanda community 9 as they each mapped to communities that corresponded to another community (6 and 1, respectively) with a higher Jaccard index