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Comparisons of three typical fusidane BGCs in fungi. (A) Synteny plots of BGCs for helvolic acid, cephalosporin P1, and fusidic acid in Aspergillus fumigatus, Acremonium chrysogenum, and Fusidium coccineum. Homologs are shown as identically colored regions linked across BGCs, whereas the percentages indicate the sequence similarity between homologs. (B) Schematic diagram of the inferred biosynthetic pathways for three fusidane-type antibiotics.
