Skip to main content
. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Adv Exp Med Biol. 2021;1287:105–122. doi: 10.1007/978-3-030-55031-8_8

Table 8.2.

Summary of NOTCH role as tumor suppressor in HNSCC

References Tumor sample (n) Sample Method Observed effect Prediction/Implication
Agrawal et al. (2011) 120 HNSCC tissues Exome Sequencing Mutated NOTCH1 Inactive protein
Stransky et al. (2011) 74 HNSCC tissues Exome Sequencing Mutated NOTCH1
NOTCH2
NOTCH3		 Inactive protein
Pickering et al. (2013) 44 HNSCC tissues Integrated genome analysis Mutated NOTCH1, NOTCH2 Inactive protein
Kandoth et al. (2013) 306 HNSCC tissues Exome sequencing-TGCA Mutated NOTCH1 Inactive protein
Song et al. (2014) 13 HNSCC cell lines Single molecule DNA sequencing Mutated NOTCH Inactive protein
Fukusumi et al. (2018) 520 HNSCC tissues TCGA Mutated NOTCH Inactive protein
Pickering et al. (2013) In vitro Overexpression of NICD Inhibition of tumor growth Tumor suppressor