Table 2.
Dose 1 (n=12) | Dose 2 (n=11) | Dose 3 (n=10) | F(2, 19) | p-Value | |
---|---|---|---|---|---|
MEQ subscales | |||||
Mystical (unity, noetic, sacred) | 0.53 (0.37–0.69) | 0.60 (0.44–0.76) | 0.65 (0.48–0.82) | 1.10 | 0.354 |
Positive mood | 0.68 (0.56–0.80) | 0.64 (0.51–0.77) | 0.72 (0.58–0.85) | 0.60 | 0.56 |
Transcendence of time and space | 0.54 (0.40–0.68) | 0.65 (0.51–0.79) | 0.73 (0.58–0.88) | 5.73 | 0.011 |
Ineffability | 0.73 (0.62–0.85) | 0.78 (0.66–0.90) | 0.81 (0.69–0.94) | 0.38 | 0.38 |
MEQ total score | 0.58 (0.46–0.71) | 0.64 (0.51–0.77) | 0.70 (0.56–0.83) | 1.70 | 0.209 |
Rate of complete mystical experience | 33.3% (n=4) | 45.5% (n=5) | 30.0% (n=3) | ||
Pharmacokinetics | |||||
AUC 0–12 h | 77 (54–100) | 124 (101–148) | 151 (127–174) | 41.8 | <0.001 |
Maximum concentration (ng/mL) | 16.9 (11.4–22.4) | 28.1 (22.4–33.8) | 35.9 (29.9–41.9) | 17.5 | <0.001 |
ANOVA: analysis of variance; AUC: area under the curve; CI: confidence interval; MEQ: Mystical Experience Questionnaire.
Results reported as estimated mean (95% CI) percentage of the maximum total score from the repeated measures ANOVA (RM-ANOVA).