Table 2.
Association between lifetime alcohol consumption and risk of MDS by sex
| Males | Females | Combined | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases, n (%) | Controls, n (%) | Crude OR (95%CI) | Adjusted OR (95% CI)a | Cases, n (%) | Controls, n (%) | Crude OR (95%CI) | Adjusted OR (95% CI)a | Crude OR (95%CI) | Adjusted OR (95% CI)a | |
| Alcohol consumption at 23–30 years | ||||||||||
| Abstainer | 33 (13) | 57 (13) | 0.85 (0.50, 1.45) | 0.81 (0.47, 1.41) | 31 (22) | 55 (21) | 1.21 (0.70, 2.09) | 1.43 (0.79, 2.59) | 1.01 (0.70, 1.49) | 1.07 (0.72, 1.60) |
| Occasional | 67 (26) | 99 (23) | Ref | Ref | 57 (40) | 124 (48) | Ref | Ref | Ref | Ref |
| Light | 113 (45) | 207 (47) | 0.81 (0.55, 1.20) | 0.73 (0.48, 1.10) | 27 (19) | 36 (14) | 1.74 (0.96, 3.16) | 1.51 (0.71, 2.89) | 1.05 (0.77, 1.42) | 0.95 (0.69, 1.31) |
| Moderate/Heavy | 40 (16) | 73 (17) | 0.87 (0.53, 1.43) | 0.71 (0.41, 1.22) | 27 (19) | 44 (17) | 1.49 (0.82, 2.69) | 1.46 (0.77, 2.79) | 1.11 (0.76, 1.63) | 0.96 (0.64, 1.45) |
| Alcohol consumption at 31–49 years | ||||||||||
| Abstainer | 40 (16) | 71 (16) | 0.89 (0.53, 1.47) | 0.92 (0.55, 1.57) | 28 (20) | 56 (22) | 0.90 (0.52, 1.57) | 1.07 (0.59, 1.95) | 0.90 (0.62, 1.31) | 1.00 (0.68, 1.48) |
| Occasional | 61 (24) | 99 (23) | Ref | Ref | 63 (44) | 117 (45) | Ref | Ref | Ref | Ref |
| Light | 99 (40) | 187 (43) | 0.83 (0.55, 1.25) | 0.80 (0.52, 1.21) | 21 (15) | 42 (16) | 0.89 (0.48, 1.64) | 0.91 (0.47, 1.80) | 0.88 (0.64, 1.20) | 0.85 (0.61, 1.19) |
| Moderate/Heavy | 52 (20) | 79 (18) | 1.04 (0.65, 1.68) | 0.92 (0.56, 1.53) | 29 (21) | 44 (17) | 1.20 (0.68, 2.11) | 1.21 (0.65, 2.45) | 1.11 (0.78, 1.60) | 1.03 (0.70, 1.51) |
| Alcohol consumption at 50–65 years | ||||||||||
| Abstainer | 62 (25) | 100 (23) | 1.08 (0.69, 1.70) | 0.99 (0.62, 1.59) | 44 (32) | 65 (26) | 1.33 (0.81, 2.20) | 1.56 (0.91, 2.66) | 1.18 (0.85, 1.66) | 1.21 (0.85, 1.71) |
| Occasional | 61 (25) | 106 (25) | Ref | Ref | 59 (42) | 119 (47) | Ref | Ref | Ref | Ref |
| Light | 73 (29) | 145 (33) | 0.86 (0.56, 1.32) | 0.80 (0.51, 1.24) | 15 (11) | 31 (12) | 0.88 (0.43, 1.79) | 0.88 (0.41, 1.88) | 0.90 (0.64, 1.27) | 0.86 (0.60, 1.23) |
| Moderate/Heavy | 52 (21) | 82 (19) | 1.09 (0.68, 1.75) | 0.99 (0.60, 1.63) | 22 (15) | 38 (15) | 1.21 (0.65, 2.25) | 1.14 (0.57, 2.24) | 1.15 (0.80, 1.67) | 1.08 (0.73, 1.60) |
| Alcohol consumption within 1 year | ||||||||||
| Abstainer | 46 (18) | 79 (18) | 0.92 (0.58, 1.46) | 0.94 (0.58, 1.52) | 40 (28) | 77 (30) | 0.87 (0.53, 1.44) | 1.08 (0.63, 1.87) | 0.90 (0.64, 1.26) | 0.99 (0.69, 1.41) |
| Occasional | 78 (31) | 125 (29) | Ref | Ref | 63 (44) | 110 (42) | Ref | Ref | Ref | Ref |
| Light | 102 (40) | 178 (41) | 0.99 (0.68, 1.44) | 0.89 (0.60, 1.33) | 25 (18) | 31 (12) | 1.58 (0.85, 2.95) | 1.70 (0.87, 3.34) | 1.09 (0.80, 1.48) | 1.01 (0.72, 1.39) |
| Moderate/Heavy | 27 (11) | 54 (12) | 0.89 (0.51, 1.54) | 0.80 (0.45, 1.44) | 14 (10) | 42 (16) | 0.73 (0.36, 1.48) | 0.58 (0.27, 1.23) | 0.83 (0.54, 1.28) | 0.71 (0.45, 1.12) |
| Lifetime Alcohol Consumption | ||||||||||
| Abstainer | 29 (11) | 44 (10) | 0.88 (0.48, 1.60) | 0.82 (0.44, 1.53) | 24 (17) | 37 (14) | 1.08 (0.59, 2.00) | 1.34 (0.69, 2.60) | 0.99 (0.65, 1.51) | 1.04 (0.67, 1.63) |
| Occasional | 52 (20) | 71 (16) | Ref | Ref | 59 (42) | 103 (40) | Ref | Ref | Ref | Ref |
| Light | 111 (44) | 221 (50) | 0.70 (0.46, 1.08) | 0.63 (0.40, 0.99) | 27 (19) | 57 (22) | 0.84 (0.48, 1.48) | 0.73 (0.39, 1.36) | 0.79 (0.57, 1.08) | 0.71 (0.50, 0.99) |
| Moderate/Heavy | 62 (24) | 102 (23) | 0.85 (0.53, 1.37) | 0.74 (0.44, 1.24) | 32 (23) | 63 (24) | 0.92 (0.53, 1.58) | 0.82 (0.44, 1.49) | 0.91 (0.64, 1.30) | 0.79 (0.54, 1.16) |
Abbreviations: Confidence interval (CI); Myelodysplastic syndromes (MDS); Odds ratio (OR); Reference level (Ref)
Columns may not sum to totals due to missing data; matching variables included age-decile and sex
a
Adjusted for benzene exposure, BMI group, household income, radiation exposure, smoking status, and age (continuous)