Table 3.
Association between recent alcohol consumption and risk of MDS by subtype
| RA/RN/RT/RARS | RCMD | RAEB-1/RAEB-2 | MDS del(5q) | t-MDS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases, n(%) | Adjusted OR (95% CI)a | Cases, n(%) | Adjusted OR (95% CI)a | Cases, n(%) | Adjusted OR (95% CI)a | Cases, n(%) | Adjusted OR (95% CI)a | Cases, n(%) | Adjusted OR (95% CI)a | |
| n (%) | 72 (18) | 106 (27) | 128 (32) | 27 (7) | 40 (10) | |||||
| Lifetime Alcohol consumption | ||||||||||
| Abstainer | 8 (22) | 0.70 (0.28, 1.75) | 16 (15) | 1.14 (0.55, 2.34) | 17 (13) | 1.01 (0.53, 1.95) | 4 (15) | 1.08 (0.32, 3.72) | 4 (10) | 0.60 (0.16, 2.30) |
| Occasional | 19 (26) | Ref | 26 (25) | Ref | 37 (29) | Ref | 12 (44) | Ref | 12 (30) | Ref |
| Light | 25 (35) | 0.87 (0.44, 1.73) | 39 (37) | 0.73 (0.41, 1.30) | 46 (36) | 0.67 (0.40, 1.12) | 6 (22) | 0.39 (0.13, 1.19) | 14 (35) | 0.64 (0.25, 1.64) |
| Moderate/Heavy | 19 (26) | 1.13 (0.53, 2.40) | 25 (24) | 0.87 (0.46, 1.64) | 28 (22) | 0.68 (0.38, 1.22) | 5 (19) | 0.45 (0.14, 1.45) | 9 (22) | 0.80 (0.28, 2.29) |
Abbreviations: Confidence interval (CI); Myelodysplastic syndromes (MDS); MDS with deletion of 5q (MDS del(5q)); Odds ratio (OR); Reference (Ref); Refractory anemia (RA); Refractory anemia with excess blasts, types 1 (RAEB-1) and 2 (RAEB-2); Refractory anemia with ring sideroblasts (RARS); Refractory cytopenia with multilineage dysplasia (RCMD); Refractory neutropenia (RN); Refractory thrombocytopenia (RT); therapy-related MDS (t-MDS)
Columns may not sum to totals due to missing data for 2 cases, 2 controls, and excluded subgroups; MDS unclassifiable (n=21) and not-otherwise-specified (n=4) excluded from analyses; Matching variables included age-decile and sex;
Adjusted for benzene exposure, BMI group, household income, radiation exposure, smoking status, age (continuous), and sex