Figure 5.

Distribution of random effects derived shrunken TDVF₀₅ estimates. A, Shrunken median estimate and 95% CI TDVF₀₅ values separated by phenotype or study and color coded by chemical class. The vertical dotted line reflects the default uncertainty factor (UF_{H, TD} = 3.16). The distribution of shrunken median estimate TDVF₀₅ values is illustrated as the boxplot above each endpoint panel. B, Barplots showing the percentage of compounds by class whose shrunken median estimate TDVF₀₅ value exceeds or falls below the default UF_{H, TD}. Number of compounds reported in each class is the number of unique compounds, not accounting for multiple compound/endpoint combinations.