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. 2020 Jul 17;12(8):630–643. doi: 10.1093/jmcb/mjaa036

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© The Author(s) (2020). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dose‒response curves of selected top hits. (A‒C) Three proteasome inhibitors, bortezomib (A), carfilzomib (B), and MLN9708 (C), showed potent inhibitory effect on the growth of organoids. (D‒F) The PI3K/mTOR inhibitor PF04691502 (D), the survivin inhibitor YM155 (E), and the protein transporter inhibitor brefeldin A (F) inhibited organoid growth in a dose-dependent manner. Tested hit compounds were re-purchased for the dose‒response study. The effect of compounds on organoid growth was expressed as % of Control. Data shown are mean from triplicate samples with SD and analyzed using GraphPad Prism software.