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. 2020 Dec 10;28(5):483–495. doi: 10.3727/096504020X15928179818438

Figure 5.

Figure 5

LINC02163 knockdown decreases HMGA2 expression in breast cancer cells through sponging miR-511-3p. (A, B) The mRNA and protein levels of HMGA2 in LINC02163-depleted MDA-MB-231 and MCF-7 cells were analyzed using RT-qPCR and Western blotting, respectively. (C) Spearman’s correlation analysis was performed to examine the correlation between LINC02163 and HMGA2 mRNA levels in 61 breast cancer tissues (r = 0.6914, p < 0.0001). (D) The knockdown efficiency of miR-511-3p inhibitor in MDA-MB-231 and MCF-7 cells was detected using RT-qPCR. (E, F) si-LINC02163 along with miR-511-3p inhibitor or negative control (NC) inhibitor was cotransfected into MDA-MB-231 and MCF-7 cells. The mRNA and protein levels of HMGA2 were detected using RT-qPCR and Western blotting, respectively. **p < 0.01.