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The four central base pairs of the solution structures of an amide-modified self-complementary oligoribonucleotide (GCGUAM1ACGC) (purple, with amide linkage highlighted in green) overlapped with the unmodified RNA (gray), as determined by NMR spectroscopy in our previous study.3 The P-OP2 bonds aligning with amide carbonyls are indicated with red arrows. Reproduced with permission from ref 20.
