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. Author manuscript; available in PMC: 2020 Dec 21.
Published in final edited form as: Cell Metab. 2018 Aug 30;29(2):303–319.e4. doi: 10.1016/j.cmet.2018.08.004

Figure 4: Clock deficient mice on time-restricted feeding are protected from glucose intolerance and insulin resistance.

Figure 4:

A-B-C. Glucose tolerance test (ip-GTT) in (A) Bmal1LKO and littermate controls (n=8-10/group), (B) Rev-erbα/βLDKO and littermate controls (n=8-12/group), and (C) CDKO and littermate controls (n=6-8/group). Quantification of the AUC above baseline is shown in the insert. Unpaired t-test, * p<0.05, ** p<0.01, *** p<0.001.

D-E-F. Serum glucose levels in fasted (ZT22-ZT36) and refed mice (1h after IP injection of glucose (1mg/g BW) at ZT36) in (A) Bmal1LKO and littermate controls (n=4-6/group), (B) Rev-erbα/βLDKO and littermate controls (n=4-6/group), and (C) CDKO and littermate controls (n=4-6/group).

G-H-I. Corresponding serum insulin concentration.