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. 2020 Dec 15;12:12853–12865. doi: 10.2147/CMAR.S273484

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© 2020 Wang et al.

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Circ-PRKDC depletion inhibits proliferation, migration and invasion and promotes apoptosis in CRC cells. SW480 and HCT116 cells were introduced with si-NC or si-circ-PRKDC. (A) Circ-PRKDC expression was determined using qRT-PCR. (B) Cell viability was assessed using CCK-8 assay. (C) The apoptosis rate was measured via flow cytometry. (D and E) Cell migration and invasion were evaluated using transwell analysis. (F and G) Cell cycle was monitored using flow cytometry. (H) The protein level of CyclinD1 was examined using Western blot. ***P < 0.001, ****P < 0.0001.