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. 2020 Dec 15;12:12853–12865. doi: 10.2147/CMAR.S273484

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© 2020 Wang et al.

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Circ-PRKDC acts as a sponge for miR-198. (A) Circular RNA Interactome predicted that circ-PRKDC and miR-198 had targeted binding sites. (B) Luciferase activity was detected in SW480 and HCT116 cells co-transfected with WT-circ-PRKDC or MUT-circ-PRKDC and miR-NC or miR-198. (C) MiR-198 level was measured in CRC tissues and adjacent non-cancer tissues. (D) MiR-198 level was detected in FHC, SW480 and HCT116 cells. (E) The correlation between circ-PRKDC and miR-198 in CRC tissues was assessed using Spearman correlation coefficient. (F and G) The binding relationship between circ-PRKDC and miR-198 was verified via RIP analysis. (H) Circ-PRKDC level was examined in SW480 and HCT116 cells transfected with pcDNA or circ-PRKDC. (I) MiR-198 expression was measured in SW480 and HCT116 cells introduced with si-NC, si-circ-PRKDC, pcDNA or circ-PRKDC. ***P < 0.001, ****P < 0.0001.