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. 2020 Dec 15;12:12853–12865. doi: 10.2147/CMAR.S273484

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© 2020 Wang et al.

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DDR1 is a target of miR-198. (A) The predicted binding sites of miR-198 and DDR1 3ʹUTR were exhibited. (B) Luciferase activity was detected in SW480 and HCT116 cells introduced with WT-DDR1 3ʹUTR or MUT-DDR1 3ʹUTR and miR-NC or miR-198. (C and D) The mRNA and protein levels of DDR1 were measured in CRC tissues and normal tissues. (E) The correlation between miR-198 and DDR1 in CRC tissues was tested via Spearman correlation analysis. (F and G) DDR1 mRNA and protein levels were examined in FHC, SW480 and HCT116 cells. (H and I) RIP assay was used to confirm the relationship between miR-198 and DDR1. (J) Expression of miR-198 was detected in SW480 and HCT116 cells transduced with miR-NC or miR-198. (K–M) DDR1 mRNA and protein levels were measured in SW480 and HCT116 cells transfected with miR-NC, miR-198, anti-miR-NC or anti-miR-198. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.