Table 2.
Summary of Characteristics in EoE and IgE-Mediated Food Allergy
| Characteristics | IgE-Mediated Food Allergy | Eosinophilic Esophagitis |
|---|---|---|
| Sensitization site | Good evidence for Skin; airway or gut may contribute |
Uncertain |
| Effector site | Gut, skin, cardiovascular and respiratory systems | Esophagus |
| Major allergens in adult patients |
Peanut = tree nuts > shellfish >> cow’s milk | Cow’s milk > wheat = egg > soy |
| Relevant genes | Filaggrin, HLA, IL-13, TSLP, STAT6 | TSLP, Calpain 14, LRRC32, EMSY, STAT6 |
| Environmental Factors | Early acid suppression medications and delayed exposure to allergenic foods | C-section, early antibiotics and acid suppression medications |
| Specific Antibodies | IgE high, IgG4 low | IgE low, IgG4 high |
| T cells | Th2 and Treg | Th2 and Treg |
| Effector Cells | Mast cells, basophils? | Eosinophils, mast cells |