Table 1.

Patients Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF), with 6-Month Follow-Up

Variables	N=190
Age (years), mean±SD	46.7±10.7
BMI (kg/m2), mean±SD	25.0±3.9
Males, n (%)	152 (80.0%)
Characteristics of HIV infection
Risk factor IVDU, n (%)	35 (18.4%)
CDC Stage C, n (%)	51 (26.8%)
HCV coinfection, n (%)	46 (24.2%)
Second-line ART, n (%)	50 (26.3%)
Undetectable HIV-RNA at switch, n (%)	178 (93.7%)
CD4+ (cells/mL), median (IQR)	634 (439–900)
ART duration (years) in multi-experienced patients, median (IQR)	9.9 (4.8–17.8)
Third drug, n (%)
Elvitegravir	112 (59.0%)
Dolutegravir	34 (17.9%)
Darunavir/Cobicistat	44 (23.1%)
Laboratory values
Total cholesterol (mg/dL), mean±SD	195±39
HDL cholesterol (mg/dL), mean±SD	48±16
LDL cholesterol (mg/dL), mean±SD	120±35
Triglycerides (mg/dL), median (IQR)	108 (80−154)
TC/HDL-C ratio, median (IQR)	4.1 (3.4−5.0)
Blood glucose (mg/dL), mean±SD	91±21
AST (IU/L), median (IQR)	23 (19–30)
ALT (IU/L), median (IQR)	24 (17–34)
eGFR (mL/min), mean±SD	86.1±19.2
Coronary heart disease score D:A:D:* (N=70)
Low (<1.0%)	21 (30.0%)
Moderate (1-<5%)	33 (47.1%)
High (5-<10%)	12 (17.1%)
Very high (≥10%)	4 (5.7%)
Median (IQR)	1.75 (0.68–4.83)
Framingham risk score (% 10-year risk) (N=77)
Low (<5.0%)	40 (52.0%)
Moderate (5-<10%)	15 (19.5%)
High (10-<20%)	14 (18.2%)
Very high (≥20%)	8 (10.4%)
Median (IQR)	4.0 (1.0–10.0)

Note: *Estimated % of 5-year risk for coronary heart disease.

Abbreviations: IVDU, intravenous drug users; CDC, center for disease control; HCV, hepatitis C virus; eGFR, estimated glomerular filtration rate; SD, standard deviation; IQR, interquartile range; BMI, body mass index; ART, antiretroviral therapy, HDL, high density lipoprotein; LDL, low-density lipoprotein; AST, aspartate aminotransferase; ALT, alanine transaminase.