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. 2020 Dec 10;23(2):130. doi: 10.3892/mmr.2020.11769

Figure 2.

Figure 2.

BNIP3 reduces the radioresistance of nasopharyngeal carcinoma cells by affecting the viability, proliferation and migration of cells. (A) Transfection efficiency of si-BNIP3 and BNIP3 OE plasmids was detected in 5-8F and 5-8F-R cells. (B) Protein expression levels of BNIP3 were detected in the 5-8F and 5-8F-R cells transfected with si-BNIP3 or BNIP3 OE plasmids. (C) 5-8F-R and 5-8F cells transfected with si-BNIP3 or BNIP3 OE plasmids were exposed to IR, and cell viability was measured at the indicated doses. (D) A colony formation assay was used to assess the colony forming ability of the transfected 5-8F and 5-8F-R cells treated with 4 Gy IR. (E) A wound healing assay was used to assess the migratory ability of the transfected 5-8F and 5-8F-R cells treated with 4 Gy IR. *P<0.05, **P<0.001 vs. NC. BNIP3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; IR, irradiation; OE, overexpression; si-, small interfering RNA; IR, irradiation; NC, negative control.