Table III.
Comparison of body weight before and 48 h after injection of nude mice with antitumor drugs.
Weight increase after administration, g | ||||||
---|---|---|---|---|---|---|
Drug | Initial weight, g | First | Second | Third | Fourth | Fifth |
T-La (FS) | 20.540± | 0.850± | 0.850± | 0.817± | 1.017± | 2.533± |
0.3855a | 0.1839a | 0.1821a | 0.3229a | 0.3038a | 0.6800a | |
RGD-T-La (FS) | 20.360± | 0.667± | 0.783± | 1.017± | 1.467± | 0.483± |
0.2874a | 0.1382a,b | 0.1138a | 0.3229a | 0.3792a | 1.4363a | |
T-La | 19.620± | 0.300± | 0.917± | 1.333± | 0.200± | 1.917± |
0.4128a | 0.2295a,b | 0.3449a | 0.3229a | 0.4933a | 0.4936a | |
RGD-T-La | 19.940± | 0.400± | 0.383± | 0.983± | 1.400± | 0.883± |
0.5680a | 0.1000a,b | 0.2496a | 0.3229a | 0.3286a | 0.3919a | |
Cisplatin positive control | 19.680± | −0.050± | −0.950± | −1.983± | −3.683± | NA |
0.5152a | 0.3149b | 0.3871b | 0.3229b | 0.5043b | ||
PBS blank control | 20.400± | −1.067± | −0.667± | 0.017± | −2.017± | 1.267± |
0.4050a | 0.4917c | 0.4780b | 0.3229b | 0.4708c | 0.8123a |
P<0.05
P<0.001 vs. PBS blank control. T-La, Temporin-La; (FS), antitumor; (S), antitumor.