Figure 1.

Establishment of the oxaliplatin-induced peripheral neuropathic pain model. (A) Von Frey, (B) acetone drop and (C) hot plate tests were conducted, and (D) body weight and (E) motor function were measured in rats following either vehicle control or oxaliplatin administration. Measurements were obtained at 0 7, 14 and 21 days post-oxaliplatin injection. Data are presented as mean ± standard error of the mean (n=8 each group). ^**P<0.01 vs. vehicle group (repeated measures ANOVA followed by Dunnett's test).