Figure 1.

Select autophagy receptors are elevated in atgΔ yeast. (A) Scheme of the autophagy-related yeast knockout cultures that were part of the Y3K study [26]. (B) Relative protein abundances in atg1Δ or atg5Δ yeast compared to WT (mean, n = 3, respiration culture condition). P-values for the protein abundance changes were determined by a two-sided Student’s t-test. For panels B–D, the original raw data are from the Y3K data set [26]. (C) Relative protein abundances in atg1Δ or atg5Δ yeast compared to WT (mean, n = 3, fermentation culture condition). (D) Relative abundance of Atg39 across all geneΔ yeast strains in the Y3K study [26] (mean, n = 3, respiration culture condition) versus statistical significance. (E) General strategy for the discovery of autophagy-related proteins based on this work