Table 2.
Summary of Pro-Angiogenic Modifications in SAP Hydrogels
| Peptide Sequences | Pro-Angiogenic Modifications | Applications | References |
|---|---|---|---|
| RADA16-I and RADA16-I -SVVYGLR (10:1) | SVVYGLR | Facilitate angiogenesis and neurogenesis at the brain injury site | (Wang et al, 2017)77 |
| RADA16-II andRADA16-II-substance P (200:1) | Substance P | Promote angiogenesis | (Im et al, 2018)63 |
| RADA-I-GPRGDSGYRGDS or RADA-I-KLTWQELYQLKYKGI | PRGDSGYRGDS, KLTWQELYQLKYKGI | Improve angiogenesis in chicken embryo chorioallantoic membrane | (Liu et al, 2012)49 |
| KKSLSLSLSLSLSLKK | Highly vascularized after subcutaneous injection | Du et al, 201512 | |
| KSLSLSLRGSLSLSLKGRGDS or KSLSLSLRGSLSLSLKGKLTWQELYQLKYKGI | LRG, RGDS, KLTWQELYQLKYKGI | Promote tissue regeneration in ischemic tissue disease | (Kumar et al, 2015)16 |
| KSLSLSLRGSLSLSLK–G–KLTWQELYQLKYKGI | LRG, KLTWQELYQLKYKGI | Promote recovery from traumatic brain injury | (Ma et al, 2020)15 |
Abbreviations: SVVYGLR, high affinity for integrin α9β1 and α4β1; PRGDSGYRGDS, cell adhesion peptide; KLTWQELYQLKYKGI, pro-angiogenic sequence; LRG, MMP2-sensitive peptide.