TABLE 1.
Cohort demographics
| 18–30 years | 31–40 years | 41–50 years | 51–60 years | 61–80 years | r | P-value | Trend | |
|---|---|---|---|---|---|---|---|---|
| Age | 25.9 ± 3.6 | 35.8 ± 3.2 | 45.4 ± 3.0 | 55.0 ± 2.8 | 68.9 ± 5.6 | - | - | - |
| BMI | 26.5 ± 5.5 | 27.6 ± 5.7 | 25.7 ± 4.8 | 26.9 ± 3.5 | 29.1 ± 5.1 | 0.15 | .143 | - |
| Height (m) | 1.7 ± 0.1 | 1.7 ± 0.1 | 1.7 ± 0.1 | 1.7 ± 0.1 | 1.7 ± 0.1 | 0.03 | .766 | - |
| Weight (kg) | 78.3 ± 19.4 | 79.4 ± 18.3 | 76.0 ± 17.1 | 78.0 ± 10.8 | 86.3 ± 19.4 | 0.140 | .164 | - |
| HR (BPM) | 63.6 ± 8.1 | 66.5 ± 11 | 63.9 ± 10.8 | 67.7 ± 12 | 63 ± 11.4 | −0.01 | .921 | - |
| CO (L/min) | 5.5 ± 1.5 | 4.9 ± 0.9 | 5.1 ± 0.8 | 5.1 ± 1.1 | 4.7 ± 1 | −0.16 | .105 | - |
| EF (%) | 55.6 ± 4.5 | 55.8 ± 6.1 | 57.3 ± 3.7 | 57 ± 5.8 | 57 ± 6.3 | 0.11 | .289 | - |
| EDV / BSA (ml/m2) | 80.9 ± 14.4 | 70.2 ± 12.9 | 75.3 ± 11.3 | 69.6 ± 11.9 | 66.6 ± 15 | −0.28 | .005 | ↓ |
| ESV / BSA (ml/m2) | 36.1 ± 8.2 | 31.3 ± 8 | 32.3 ± 6.7 | 30.1 ± 7.4 | 29.0 ± 8.9 | −0.25 | .011 | ↓ |
| SV / BSA (ml/m2) | 44.8 ± 7.7 | 38.9 ± 7.5 | 42.9 ± 5.7 | 39.5 ± 6.9 | 37.6 ± 8.1 | −0.24 | .016 | ↓ |
| Myocardial mass / BSA (g/m2) | 52.4 ± 9.9 | 47.6 ± 6.4 | 52.7 ± 8.4 | 52.1 ± 8.4 | 56.6 ± 11.8 | 0.22 | .024 | ↑ |
| AAo Median Diameter (mm) | 26.6 ± 2.4 | 26.2 ± 2.7 | 27.8 ± 3.2 | 29.6 ± 3.4 | 31.6 ± 4.3 | 0.55 | <.001 | ↑ |
| Arch Median Diameter (mm) | 21.0 ± 2.4 | 21.4 ± 1.9 | 23.3 ± 2.1 | 24.5 ± 2.6 | 25.3 ± 2.5 | 0.60 | <.001 | ↑ |
| DAo Median Diameter (mm) | 17.2 ± 1.6 | 17.5 ± 1.9 | 18.9 ± 1.9 | 20.7 ± 2.7 | 20.7 ± 2.6 | 0.55 | <.001 | ↑ |
| AAo Median Diameter / BSA (mm/m2) | 14.1 ± 1.8 | 13.7 ± 1.7 | 14.9 ± 2.4 | 15.5 ± 2.0 | 15.8 ± 2.3 | 0.36 | <.001 | ↑ |
| Arch Median Diameter / BSA (mm/m2) | 11.1 ± 1.7 | 11.2 ± 1.4 | 12.5 ± 2.0 | 12.9 ± 1.5 | 12.6 ± 1.5 | 0.37 | <.001 | ↑ |
| DAo Median Diameter / BSA (mm/m2) | 9.1 ± 1.1 | 9.1 ± 0.9 | 10.1 ± 1.5 | 10.9 ± 1.6 | 10.3 ± 1.3 | 0.40 | <.001 | ↑ |
Note: Cohort demographic information and left-ventricular function metrics are presented as the mean ± SD. Each age group includes 10 males and 10 females. Gray rows indicate those with significant Pearson coefficients (P < .05). The median diameter in each aorta region is shown as both raw values and normalized by BSA. The significance of the Pearson correlation coefficient (r) is presented in the P-value column.
Abbreviations: BMI, body mass index; CO, cardiac output; EDV/BSA, end-diastolic volume normalized by BSA; EF, ejection fraction; ESV/BSA, end-systolic volume normalized by BSA; HR, heart rate; SV/BSA, stroke volume normalized by BSA.