TABLE 2.
Hemodynamic metrics during aging
| 18–30 years | 31–40 years | 41–50 years | 51–60 years | 61–80 years | r | P-value | Trend | |
|---|---|---|---|---|---|---|---|---|
| AAo Mean Velocity (m/s) | 0.62 ± 0.12 | 0.58 ± 0.08 | 0.61 ± 0.15 | 0.58 ± 0.10 | 0.51 ± 0.09 | −0.31 | .001 | ↓ |
| Arch Mean Velocity (m/s) | 0.62 ± 0.13 | 0.58 ± 0.09 | 0.54 ± 0.12 | 0.52 ± 0.10 | 0.43 ± 0.06 | −0.56 | <.001 | ↓ |
| DAo Mean Velocity (m/s) | 0.83 ± 0.16 | 0.73 ± 0.13 | 0.68 ± 0.16 | 0.58 ± 0.12 | 0.45 ± 0.08 | −0.71 | <.001 | ↓ |
| AAo Vmax (m/s) | 1.48 ± 0.2 | 1.37 ± 0.24 | 1.46 ± 0.28 | 1.54 ± 0.28 | 1.61 ± 0.33 | 0.25 | .012 | ↑ |
| Arch Vmax (m/s) | 1.08 ± 0.2 | 0.95 ± 0.15 | 0.9 ± 0.16 | 0.9 ± 0.2 | 0.77 ± 0.14 | −0.5 | <.001 | ↓ |
| DAo Vmax (m/s) | 1.49 ± 0.24 | 1.24 ± 0.19 | 1.15 ± 0.29 | 1.06 ± 0.2 | 0.91 ± 0.16 | −0.65 | <.001 | ↓ |
| AAo Mean 3D-WSS (Pa) | 0.67 ± 0.14 | 0.65 ± 0.11 | 0.66 ± 0.18 | 0.63 ± 0.12 | 0.54 ± 0.11 | −0.33 | .001 | ↓ |
| Arch Mean 3D-WSS (Pa) | 0.70 ± 0.15 | 0.64 ± 0.11 | 0.60 ± 0.12 | 0.61 ± 0.12 | 0.48 ± 0.09 | −0.52 | <.001 | ↓ |
| DAo Mean 3D-WSS (Pa) | 0.99 ± 0.19 | 0.84 ± 0.15 | 0.79 ± 0.17 | 0.67 ± 0.15 | 0.51 ± 0.10 | −0.73 | <.001 | ↓ |
| AAo WSSmax (Pa) | 1.22 ± 0.17 | 1.17 ± 0.15 | 1.29 ± 0.3 | 1.29 ± 0.2 | 1.25 ± 0.23 | 0.11 | .276 | - |
| Arch WSSmax (Pa) | 1.12 ± 0.22 | 0.98 ± 0.17 | 0.93 ± 0.19 | 0.98 ± 0.2 | 0.88 ± 0.26 | −0.32 | .001 | ↓ |
| DAo WSSmax (Pa) | 1.41 ± 0.28 | 1.19 ± 0.19 | 1.09 ± 0.24 | 0.98 ± 0.19 | 0.84 ± 0.16 | −0.66 | <.001 | ↓ |
| AAo Median Positive Helicity (m/s2) | 164 ± 63 | 138 ± 39 | 149 ± 80 | 135 ± 65 | 106 ± 32 | −0.32 | .001 | ↓ |
| AAo Median Negative Helicity (m/s2) | −151 ± 53 | −139 ± 38 | −156±103 | −134 ± 56 | −100 ± 40 | 0.27 | .007 | ↑ |
| Arch Median Positive Helicity (m/s2) | 163 ± 81 | 119 ± 43 | 102 ± 56 | 79 ± 37 | 56 ± 15 | −0.60 | <.001 | ↓ |
| Arch Median Negative Helicity (m/s2) | −111±45 | −91 ± 27 | −80 ± 38 | −67 ± 26 | −46 ± 12 | 0.59 | <.001 | ↑ |
| DAo Median Positive Helicity (m/s2) | 164 ± 55 | 116 ± 40 | 101 ± 53 | 80 ± 30 | 61 ± 18 | −0.64 | <.001 | ↓ |
| DAo Median Negative Helicity (m/s2) | −154± 54 | −118 ± 41 | −95 ± 43 | −81 ± 29 | −60 ± 16 | 0.63 | <.001 | ↑ |
Note: Changes in aorta hemodynamic parameters during aging are presented. Each age group includes 10 males and 10 females. Regional velocity and 3D-WSS values were measured for each of the 100 subjects (20 per age group) and correlated for this table. Maximum velocity was filtered as described in the Methods section, and maximum 3D-WSS values represent the 98% percentile of the 3D-WSS magnitude in each region. Values are reported as the mean ± SD. Gray rows indicate those with significant Pearson coefficients (r) (P < .05). The significance is indicated by the P-values.