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. 2020 Nov 13;11:572387. doi: 10.3389/fphar.2020.572387

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Copyright © 2020 Wang, Yang, Zhong, Jiang, Zhang, Kwan and Su

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Zanthoxylum bungeanum Maxim (ZBM) induces apoptosis in 3T3-L1 adipocytes. (A) Cell viability of 3T3-L1 after ZBM treatment at the indicated time points. (B) Apoptotic cell distribution and the percentages of apoptotic cells after ZBM treatments. (C) Expressions of cleaved poly (ADP-ribose) polymerase (PARP), Bax, Bcl-2, and Mcl-1 in 3T3-L1 cells after ZBM treatment, and the quantitative analysis of the corresponding protein expressions. (D) Expressions of cleaved PARP (c-PARP), cleaved caspase 3 (c-casp 3), cleaved caspase 6 (c-casp 6), cleaved caspase 7 (c-casp 7), cleaved caspase 8 (c-casp 8), and cleaved caspase 12 (c-casp 12) in 3T3-L1 cells after quercetin treatment and the quantitative analysis of the corresponding protein expressions. The data are shown as the means ± SEM, n = 3 individual experiments, *p < 0.05, **p < 0.01 compared to control.