FIGURE 5.

Effects of CD treatment on the p62-NFE2L2/Keap1 signaling pathway in WT mice with APAP-induced ALI. (A–D) Liver tissue was collected 6 h after APAP challenge and analyzed by western blot for assessment of nuclear abundance of NFE2L2, protein abundance of Keap1, and the phosphorylation of p62 at ser349. β-Actin or Lamin B1 was used as an internal control. Similar results were obtained from three independent experiments. All data are presented as means ± SEM (n = 10 in each group). *p < 0.05 and **p < 0.01 vs. control group; ^# p < 0.05 and ^## p < 0.01 vs. APAP group.