Table 1.

List of DRSS Endpoints

Endpoints		Definition of Endpoints Based on Change in DRSS Steps From Baseline
Binary	% ≥3-step progression	Classify patients into those with ≥3-step progression or not
	% ≥2-step progression	Classify patients into those with ≥2-step progression or not
	% ≥3-step improvement	Classify patients into those with ≥3-step improvement or not
	% ≥2-step improvement	Classify patients into those with ≥2-step improvement or not
Ordinal	% ≥3-step progression, no change, ≥3-step improvement	Classify patients into those with ≥3-step progression or with ≥3-step improvement or neither
	% ≥2-step progression, no change, ≥2-step improvement	Classify patients into those with ≥2-step progression or with ≥2-step improvement or neither
	Change in ETDRS severity steps	No further derivation of change in DRSS steps

Abbreviations: DRSS, Diabetic Retinopathy Severity Scale; ETDRS, Early Treatment Diabetic Retinopathy Study.