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. 2020 Dec 17;14:5547–5558. doi: 10.2147/DDDT.S280922

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© 2020 Li et al.

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OI activates Nrf-2-dependent antioxidant and anti-inflammatory effects. Nrf-2 and Nrf-2-target genes were upregulated by OI. The expression of Nrf-2, HO-1, and Nqo-1 in lung tissue are presented (A–E, n = 3). RAW264.7 cells were pretreated with OI (3 h), followed by stimulation with LPS (1µg/mL). The protein content of Nrf-2 and HO-1 was measured by Western blot (F–H, n = 3), and the mRNA of HO-1 and Nqo-1 (6 h) was detected by qPCR (I and J, n = 3). The results are presented as means ±SD. *P < 0.05 compared with ALI group. ^#P < 0.05 compared with the group only treated by 1μg/mL LPS.