Table 1.
Clinicopathological Characteristics of 40 HBV-Related HCC Patients Enrolled in This Study
| Characteristicsa | No. of Patients | Median (Range) |
|---|---|---|
| Age (years) | 40 | 54 (28–78) |
| >50 | 29 | 58 (51–78) |
| ≤50 | 11 | 47 (28–49) |
| Gender (men/women) | 34/6 | |
| Smoking (yes/no) | 14/26 | |
| Alcohol (yes/no) | 9/31 | |
| HBsAg (positive/negative/NA)b | 36/0/4 | |
| HBeAg (positive/negative)c | 6/34 | |
| HBV genotype (B/C) | 31/9 | |
| HBV DNA (copies/mL) (20–1.47×108/<20/NA)d | 36/2/2 | 1.1×105(30.1–1.5×108) e |
| >1×104 | 24 | 4.5×105(1.2×104–1.5×108) |
| ≤1×104 | 12 | 4.2×102(30.1–6.3×103) |
| Albumin (g/dL) | 40 | 3.8 (2.0–4.9) |
| >3.8 | 18 | 4.2 (3.9–4.9) |
| ≤3.8 | 22 | 3.4 (2.0–3.8) |
| AST (U/L) | 40 | 37.5 (3–305) |
| >34 | 32 | 64.5 (35–290) |
| ≤34 | 8 | 25.0 (14–34) |
| ALT (U/L) | 40 | 55.5 (13–292) |
| >40 | 26 | 80.0 (42–292) |
| ≤40 | 14 | 33.0 (13–40) |
| AFP (ng/mL) (≤54,000/>54,000)f | 35/5 | 37.7 (1.4–4,550.0) g |
| >400 | 10 | 823.6 (412.3–4,550.0) |
| ≤400 | 25 | 20.2 (1.4–280.7) |
| Tumor size (cm) | 39 | 4.0 (1.5–35.0) |
| >5 | 14 | 10.0 (5.5–35.0) |
| ≤5 | 25 | 3.0 (1.5–11.0) |
| Tumor encapsulation (yes/no/NA) | 30/9/1 | |
| Satellite nodule (yes/no) | 7/33 | |
| Lymph node involvement (yes/no) | 6/34 | |
| Portal vein thrombosis (yes/no) | 1/39 | |
| Vascular invasion (yes/no) | 18/22 | |
| Distant metastasis (yes/no) | 4/36 | |
| Steatosis grade (0/1/2/3/NA) | 23/9/1/0/7 | |
| Metavir inflammation score (0/1/2/3/NA) | 5/29/1/0/5 | |
| Ishak fibrosis score (0/1/2/3/4/5/6/NA) | 1/6/8/9/10/1/4/1 | |
| Child-Pugh cirrhosis score (A/B/C) | 30/7/3 | |
| CLIP score (0/1/2/3/4/5/6) | 16/14/6/2/1/0/1 | |
| BCLC stage (A/B/C/D) | 25/7/5/3 | |
| AJCC TNM stage (I/II/IIIA/IIIB/IIIC/IVA/IVB) | 17/14/4/1/3/0/1 |
Notes: aOnly patients with available data were analyzed. b, cHBsAg and HBeAg were detected by enzyme-linked immunosorbent assay (Abbott Laboratories, Abbott Park, IL, USA). dHBV DNA was measured by TagMan PCR (Roche Diagnostics, Indianapolis, IN, USA) with a detection range of 20–1.47×108 copies/mL. e, gOnly data within the detection range were analyzed. fAFP was measured with the highest detection limit of 54,000 ng/mL.
Abbreviations: HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HBeAg, hepatitis B e antigen; NA, not available; AST, aspartate aminotransferase; ALT, alanine aminotransferase; AFP, alpha-fetoprotein; CLIP, Cancer of the Liver Italian Program; BCLC, Barcelona Clinic Liver Cancer; AJCC, American Joint Committee on Cancer; TNM, tumor-node-metastasis.