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. 2020 Nov 17;11:557789. doi: 10.3389/fphar.2020.557789

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Copyright © 2020 Garcia, Isca, Pereira, Monteiro, Ntungwe, Sousa, Dinic, Holmstedt, Roberto, Díaz-Lanza, Reis, Pesic, Candeias, Ferreira, Duarte, Afonso and Rijo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Natural and semisynthetic royleanones: 6,7-dehydroroyleanone (1) and 7α-acetoxy-6β-hydroxyroyleanone (2), 6,7-dihydroxyroyleanone (3), 7α-acetoxy-6β-benzoyloxy-12-O-(4-chloro)benzoylroyleanone (4) and 7α-acetoxy-6β-benzoyloxy-12-O-benzoylroyleanone (5).