TABLE 1.

Key events portraying the well-approved clinical uses of hydroxychloroquine (HCQ) and chloroquine (CQ) along with the historical evolution of their utilization in the medical field (Schrezenmeier and Dörner, 2020).

Year	Event
1630	Quinine powder extracted from the tree of cinchona was used in the treatment of malaria
1934	Synthetic CQ was first produced
1949	The U.S Food and Drug Administration authorized the use of CQ in the management of rheumatic and skin diseases
1950	Synthetic HCQ was first produced
1955	The U.S Food and Drug Administration authorized the use of HCQ in the management of rheumatic and skin diseases