Table 3.
Hazard ratios of subgroup analysis for ECH patients stratified by primary ECH diagnosis, presence of severe or non-severe ECH, presence/absence of gastrointestinal-type (GI) ECH, history of GI/GU cancer, age, and CHA2DS2-VASc score.
| Overall HRs | ||||
|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | |
| Primary ECH diagnosis (n= 710,693) |
1.22 (1.16–1.27) |
1.16 (1.11–1.21) |
1.18 (1.13–1.24) |
1.17 (1.12–1.22) |
| Severe ECH (n= 708,532) |
1.23 (1.17–1.30) |
1.17 (1.11–1.24) |
1.21 (1.14–1.27) |
1.12 (1.06–1.18) |
| Non-severe ECH (n= 721,335) |
1.10 (1.06–1.15) |
1.09 (1.05–1.14) |
1.11 (1.06–1.16) |
1.07 (1.02–1.12) |
| GI ECH (n= 732,383) |
1.23 (1.17–1.28) |
1.16 (1.11–1.21) |
1.18 (1.13–1.24) |
1.15 (1.10–1.20) |
| Non-GI ECH (n= 667,827) |
1.01 (0.88–1.17) |
1.05 (0.91–1.21) |
1.09 (0.94–1.26) |
0.96 (0.83–1.11) |
| History of GI/GU cancer (n= 43,117) |
1.46 (1.25–1.71) |
1.39 (1.19–1.62) |
1.40 (1.20–1.64) |
1.40 (1.20–1.63) |
| No history of GI/GU cancer (n= 718,666) |
1.15 (1.11–1.19) |
1.12 (1.08–1.16) |
1.14 (1.10–1.19) |
1.09 (1.05–1.13) |
| Age < 60 years (n= 91,959) |
1.01 (0.83–1.22) |
1.00 (0.82–1.20) |
0.93 (0.77–1.13) |
0.94 (0.78–1.14) |
| Age >= 60 years (n= 671,807) |
1.13 (1.09–1.17) |
1.13 (1.09–1.17) |
1.16 (1.12–1.20) |
1.09 (1.06–1.14) |
| CHA2DS2-VASc score < 2 (n= 130,424) |
1.21 (1.05–1.41) |
1.18 (1.02–1.37) |
1.17 (1.00–1.36) |
1.20 (1.03–1.39) |
| CHA2DS2-VASc score ≥ 2 (n= 633,833) |
1.11 (1.07–1.15) |
1.12 (1.08–1.16) |
1.15 (1.10–1.19) |
1.08 (1.04–1.12) |
Model 1: unadjusted
Model 2: Adjusted for age and sex
Model 3: Adjusted for age, sex, smoking status, CHF, CHD, HLD, HTN, DM, PVD, CKD
Model 4: Adjusted for CHA2DS2-VASc score
ECH characteristic subgroups may not add up to total N of study (N= 764,257) because the unexposed (no ECH) group is unchanged in these subgroups.