Table 2.

Characteristic of Intracranial Lesion at Start of ICIs

	pBM Group	aBM Group p value
Size of intracranial lesion(maximum diameter)			0.649&
≥3cm	16(23.2%)	3(27.5%)
<3cm	53(77.8%)	5(62.5%)
Edema size			0.895&
≥3cm	19(27.5%)	3(27.5%)
<3cm	50(72.5)	5(62.5%)
Number of total lesions			0.271#
<3	35(50.7%)	6(75%)
≥3	34(49.3%)	2(25%)
Meningeal metastasis			0.493&
Yes	11(15.9%)	0(0%)
No	58(84.1%)	8(100%)
DS-GPA score			0.677*
0–1	24(34.8%)	2(25%)
1.5–2.5	42(60.9%)	6(75%)
3–4	3(4.3%)	0(0%)

Notes: *Pearson’s chi-squared test; # Fisher’s Exact Test; & Continuous correction.

Abbreviations: ICIs, immune checkpoint inhibitors; DS-GPA, disease-specific graded prognostic assessment; pBM, patients with brain metastasis prior to ICIs treatment; aBM group, patients with brain metastasis after ICIs treatment.