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. 2020 Dec 14;13:12829–12843. doi: 10.2147/OTT.S283786

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© 2020 Deng et al.

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TAMs-Mφs could inhibit HepG2 cells’ apoptosis and activate the CCAT1/let-7b/HMGA2 signaling pathway in HepG2 cells. (A) TUNEL staining (scar bar = 100 μm) and (B–C) flow cytometry were performed to detect the effect of M0-Mφs and TAMs-Mφs supernatant on the apoptosis of HepG2 cells. (D) Effect of M0-Mφs and TAMs-Mφs supernatant on the expression of CCAT1, let-7b, and HMGA2 was detected via real-time PCR. (E) HMGA2 expression was observed through the Western blot assay. (F) Effect of M0-Mφs and TAMs-Mφs on the expression of CCAT1, let-7b, and HMGA2 was detected via real-time PCR. (G) HMGA2 expression was observed via Western blot assay. **p < 0.01 or *p < 0.05.