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Diagram of the crosstalk between HepG2 cells and TAMs-like macrophages. Over-expression of HMGA2 significantly promoted the proliferation, migration, and invasion of HepG2 cells and increased the secretion of CSF1, which could accelerate the migration of TAMs-Mφs. Moreover, the recruited TAMs-Mφs could promote the HCC progression by activating the CCAT1/let-7b/HMGA2 signaling pathway.
