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. Author manuscript; available in PMC: 2020 Dec 21.
Published in final edited form as: Mol Cell. 2019 Aug 20;76(1):126–137.e7. doi: 10.1016/j.molcel.2019.07.001

Figure 3. Members of the methionine biosynthesis pathway are regulated by K11-linked ubiquitin chains independent of protein stability.

Figure 3.

(A) Global half-life analysis of proteomes of WT and ubiquitin K11R strains. Scatterplot comparing the half-life of whole proteome (n = 1,375, grey points) with proteins showing increased abundance in K11R mutants (upper right quadrant Figure 2A; i.e. potential K11 modified proteasome substrates) (n = 69, red points) are displayed.

(B and C) Decay curves for Sam4 (B) and Met6 (C), respectively.

(D) Correlations between the proteome and transcriptome. The Pearson correlation coefficient was 0.86.