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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Curr Opin Solid State Mater Sci. 2020 Nov 29;25(1):100873. doi: 10.1016/j.cossms.2020.100873

Table 1.

Summary of the impact of nanotopographical features on YAP translocation and stem differentiation*

Cell type Topography Diameter Height Pitch Material Culture condition Effect on differentiation Yap translocation ref
hMSCs** Rough surface 200nm Not mentioned Not mentioned glass conditioned osteogenic media, Day 3 on topography Enhancement of hMSC Osteogenesis (TAZ) Cytosol to nucleus [103]
iPSC*** Nanopillar,nanograting 500nm 560nm 500nm-1μm PDMS neurogenic media, Day 6 in culture Promote neuronal differentiation Nucleus to cytosol [104]
MSC Nanorod 200nm 1.8-2.5μm dense bulk metallic glass Media with adipogenic and osteogenic factors mix, 24 h on nanorod Promote adipogenesis Nucleus to cytosol [105]
HUVEC**** and hMSC Nanoneedle 50nm-700nm at the tip 3-4μm Around 2μm silicon Basal media with no induction factor, 6h/24h post seeding Promote adipogenesis in adipogenic media. Not 700nm but 50nm nanoneedles inhibit osteogenesis in osteogenic media. No effect in basal media. Nucleus to cytosol [106, 107]
*

Studies of Tissue/Embryo differentiation is not included

**

hMSC: human mesenchymal stem cell

***

iPSC: Induced pluripotent stem cells

****

HUVEC: Human umbilical vein endothelial cells