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. 2020 Dec 21;10(8):e262. doi: 10.1002/ctm2.262

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© 2020 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Extracellular vesicles’ (EVs) delivery does not impair physiological hearing in vivo. A, The intracochlear delivery of 1 μL of EVs from umbilical cord‐derived mesenchymal stromal cells (UC‐MSCs) to normal hearing mice does not negatively affect hearing as shown by auditory brainstem response (ABR) thresholds (green) when compared to the ABR before the EV treatment (black). B, The outer hair cell function evaluated by distortion product otoacoustic emission (DPOAE) testing is also not impaired in response to EV delivery (green line) when tested at day 5 postdelivery (blue line) and compared to the DPOAEs before EV application. Pink and rose lines represent the noise floor. Abbreviations: dB, decibel; F, frequency; kHz, kiloHertz; SPL, sound pressure level