TABLE 2.
Blood pressure and pulse wave velocity parameters corrected for DBP
| Heart rate (HR) | HR dependence | ||||||
| 300 bpm | 350 bpm | 400 bpm | 450 bpm | 500 bpm | Slope | P | |
| DBP | |||||||
| 60 mmHg | |||||||
| SBP (mmHg) | 109 ± 2 | 102 ± 2 | 100 ± 2 | 96 ± 2 | 93 ± 3 | −7.7 ± 0.5 | <0.001 |
| MAP (mmHg) | 80 ± 1 | 77 ± 1 | 76 ± 1 | 74 ± 1 | 74 ± 1 | −2.6 ± 0.2 | <0.001 |
| PWVTT, m/s | 3.49 ± 0.13 | 3.51 ± 0.13 | 3.53 ± 0.13 | 3.54 ± 0.13 | 3.54 ± 0.14 | 0.03 ± 0.01 | 0.023 |
| PWVdist, m/s | 3.60 ± 0.14 | 3.62 ± 0.14 | 3.72 ± 0.14 | 3.77 ± 0.14 | 3.80 ± 0.14 | 0.11 ± 0.04 | 0.003 |
| 85 mmHg | |||||||
| SBP (mmHg) | 148 ± 2 | 140 ± 2 | 136 ± 2 | 130 ± 2 | 126 ± 2 | −10.6 ± 0.5 | <0.001 |
| MAP (mmHg) | 109 ± 1 | 106 ± 1 | 105 ± 1 | 103 ± 1 | 101 ± 1 | −3.9 ± 0.2 | <0.001 |
| PWVTT, m/s | 3.79 ± 0.13 | 3.83 ± 0.13 | 3.85 ± 0.13 | 3.90 ± 0.13 | 3.91 ± 0.13 | 0.06 ± 0.01 | <0.001 |
| PWVdist, m/s | 4.32 ± 0.13 | 4.39 ± 0.12 | 4.54 ± 0.12 | 4.47 ± 0.12 | 4.56 ± 0.12 | 0.11 ± 0.03 | 0.001 |
| 110 mmHg | |||||||
| SBP (mmHg) | 181 ± 3 | 175 ± 3 | 172 ± 3 | 167 ± 3 | 162 ± 3 | −9.2 ± 0.7 | <0.001 |
| MAP (mmHg) | 137 ± 1 | 135 ± 1 | 134 ± 1 | 132 ± 1 | 130 ± 1 | −3.7 ± 0.2 | <0.001 |
| PWVTT, m/s | 4.49 ± 0.14 | 4.47 ± 0.14 | 4.51 ± 0.14 | 4.55 ± 0.14 | 4.59 ± 0.14 | 0.06 ± 0.02 | 0.001 |
| PWVdist, m/s | 5.51 ± 0.16 | 5.29 ± 0.16 | 5.45 ± 0.15 | 5.42 ± 0.15 | 5.38 ± 0.15 | −0.02 ± 0.05 | 0.686 |
| DBP dependence | |||||||
| Slope | |||||||
| SBP (mmHg) | 144 ± 4 | 146 ± 4 | 144 ± 4 | 141 ± 4 | 139 ± 4 | ||
| MAP (mmHg) | 117 ± 1 | 117 ± 1 | 116 ± 1 | 114 ± 1 | 112 ± 1 | ||
| PWVTT, m/s | 2.0 ± 0.2 | 1.9 ± 0.2 | 2.0 ± 0.2 | 2.0 ± 0.2 | 2.1 ± 0.2 | ||
| PWVdist, m/s | 3.8 ± 0.4 | 3.3 ± 0.4 | 3.5 ± 0.4 | 3.3 ± 0.4 | 3.2 ± 0.4 | ||
Values denote mean ± standard error. SBP, mean arterial pressure (MAP), transit time pulse wave velocity (PWVTT), and distensibility-based pulse wave velocity (PWVdist) as a function of DBP (vertically) and heart rate (HR) (horizontally). Note that values in each row are corrected to a fixed DBP of 60, 85, or 110 mmHg. Hence, as expected, the decreasing pulse pressure with increasing heart rate leads to a decrease in both SBP and MAP with heart rate. HR and DBP dependences are given in units of measurement per 100 bpm or per 100 mmHg, respectively. DBP dependences were calculated at 85 mmHg. All values are corrected for age. P denotes P-value for slope. For DBP dependence, all P < 0.001.