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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Microcirculation. 2020 May 25;27(6):e12624. doi: 10.1111/micc.12624

FIGURE 2.

FIGURE 2

Effect of ABT-702 treatment on coronary arteriole dilation in obese ZSF1 rats. Panel A, Western immunoblot and summary data (n = 4 in each group) of ADK levels in lean (LN) and obese (OB) ZSF1 rats. Panels B&C, Representative immunofluorescence images of coronary arterioles in lean and obese ZSF1 rats (ADK in red:, 4′,6-Diamidino-2-phenylindole dihydrochloride in Blue: Green is autofluorescence). Summary data show coronary arteriole (Panels D-F) and femoral artery (Panels G-I): dilations in response to cumulative concentrations of acetylcholine (1 nmol/L-1 μmol/L, or 1 nmol/L-10 μmol/L in the femoral artery), sodium-nitroprusside (1 nmol/L-1 μmol/L) and adenosine (1 nmol/L-10 μmol/L) in lean and obese ZSF1 rats with and without in vivo ABT-702 treatments (n = 4 in each group). *P < .05 lean vs obese ZSF1 rats. #P < .05 between obese vehicle and obese ABT-702 treated rats