Table 4.
Chronological changes in the secondary outcomes between the 2 groups.
| Measurement and group | ||||||||||||||||||
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Values | Two-way repeated measures ANOVA | ||||||||||||||||
|
|
Baselinea | 0.5 months |
1 month |
2 months |
3 months |
4 months |
5 months |
Within groups | Between groups | Interaction |
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|
|
F value |
P value |
F value |
P value |
F value |
P value |
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| Urine salinity (g)b, mean (SD) | ||||||||||||||||||
|
|
Intervention group (N=204) | 8.04 (2.71) | 10.36 (3.11) | 10.71 (2.69) | 10.85 (2.74) | 10.75 (2.80) | 10.59 (2.82) | 10.18 (2.84) | 1.91 | .09 | 2.97 | .01 | 1.62 | .15 |
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|
|
Control group | 8.23 (3.05) | 10.93 (2.88) | 10.58 (2.94) | 10.78 (3.20) | 10.75 (3.05) | 10.58 (3.20) | 10.30 (3.21) |
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|
|
|
|
|
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| Systolic blood pressure (mmHg), mean (SD) | ||||||||||||||||||
|
|
Intervention group (N=204) | 136.9 (19.2) | 130.0 (16.7) | 128.4 (17.1) | 127.6 (15.4) | 127.9 (17.5) | 127.2 (15.7) | 125.7 (16.1) | 9.95 | <.001 | 4.42 | .04 | 1.7 | .12 |
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|
|
Control group (N=208) | 136.9 (19.3) | 132.4 (16.3) | 132.3 (16.2) | 131.7 (16.1) | 132.1 (17.2) | 131.6 (16.7) | 128.3 (15.4) |
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|
|
|
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| Diastolic blood pressure (mmHg), mean (SD) | ||||||||||||||||||
|
|
Intervention group (N=204) | 89.4 (9.9) | 86.3 (9.3) | 84.6 (9.0) | 84.9 (8.3) | 85.3 (9.3) | 85.1 (8.4) | 84.4 (8.0) | 7.71 | <.001 | 5.82 | .02 | 0.38 | .89 |
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|
|
Control group (N=208) | 90.5 (10.4) | 87.9 (9.6) | 87.0 (9.7) | 86.5 (9.5) | 87.5 (10.3) | 87.4 (10.0) | 86.1 (9.3) |
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|
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|
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| Quality of life (EQ-5D-5L score), mean (SD) | ||||||||||||||||||
|
|
Intervention group (N=204) | 0.70 (0.10) |
|
|
0.76 (0.11) |
|
|
0.75 (0.09) | 21.58 | <.001 | 17.83 | <.001 | 0.13 | .88 |
|
|||
|
|
Control group (N=208) | 0.71 (0.10) |
|
|
0.76 (0.11) |
|
|
0.75 (0.09) |
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aBaseline comparison was tested in each item and no significant differences were observed.
bBaseline data of urinary salt excretion was excluded from analysis because it was collected from spot urine, whereas we have collected the overnight urine from the rest of the months.