Table 1.

Results of lymphocyte transformation test (LTT) and RUCAM scores

Antidepressant drug	Class	Drug concentration
		0.1 µg/mL	1 µg/mL	10 µg/mL	50 µg/mL	Result	RUCAM
		Stimulation index (SD)					Score a 1st	Score b 2nd
Amitriptyline	TCA	0.5 (0.2)	0.5 (0.1)	0.3 (0.1)	0.3 (0.1)	Negative	Not involved	Not involved
Aripiprazole	SNRI	4.2 (0.7)	3.3 (0.4)	2.2 (0.4)	3.8 (0.6)	Positive	Not involved	Not involved
Clomipramine	TCA	0.8 (0.1)	2.3 (0.3)	0.5 (0.1)	0.2 (0.0)	Positive	Not involved	+9
Escitalopram	SSRI	0.3 (0.1)	0.7 (0.2)	0.7 (0.3)	0.3 (0.0)	Negative	Not involved	Not involved
Lorazepam	BZD	‐	‐	‐	‐	‐	+2	+2
Maprotiline	TeCA	0.1 (0.0)	0.2 (0.1)	3.0 (0.8)	0.3 (0.1)	Positive	Not involved	Not involved
Midazolam	BZD	‐	‐	‐	‐	‐	+2	+2
Sertraline	SSRI	3.9 (0.8)	1.4 (0.1)	0.8 (0.1)	0.2 (0.0)	Positive	Not involved	Not involved
Trazodone	SSRI	0.4 (0.2)	0.7 (0.1)	1.6 (0.6)	1.2 (0.2)	Negative	Not involved	+6
Venlafaxine	SNRI	0.8 (0.2)	2.0 (0.2)	4.0 (0.9)	2.7 0.1)	Positive	+10	Not involved
Vortioxetine	SSRI	0.5 (0.0)	0.3 (0.0)	0.4 (0.1)	0.3 (0.1)	Negative	Not involved	+10

Abbreviations: BZD, benzodiazepine; NDRI, norepinephrine‐dopamine reuptake inhibitor; RUCAM, Roussel Uclaf Causality Assessment Method; SD, Standard Deviation; SNRI, serotonin and norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, Tricyclic antidepressant; TeCA, Tetracyclic antidepressant.

^aBefore hospitalization.

^bDuring hospitalization.