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Cisplatin has a dual-effect on cancerogenesis, which hinges on the type of cancer and the circadian genes involved.
| Cancer Type | Circadian Gene | Cancer | Reference |
|---|---|---|---|
| Leukemia | BMAL1 | Increase | Rahman et al. (2017) |
| Breast Cancer | CLOCK, CRY1, CRY2, PER1, PER2, PER3 | Decrease | Lesicka et al. (2018) |
| Lung Cancer | CLOCK, PER1, PER2, PER3 | Decrease | Liu et al. (2014) |
| Ovarian Cancer | CLOCK | Decrease | Xu et al. (2018) |
