Table 2.
Factors showing significant or borderline significant association with placental inositol.
| Categorical variable | Unadjusted β (95% CI) placental inositol z-score (SDs) | P value | Adjusted β (95% CI)a placental inositol z-score (SDs) | P value |
|---|---|---|---|---|
| Tobacco smoke exposure | ||||
| No | Reference | Reference | ||
| Yes | 0.22 (0.08, 0.36) | 0.002 | 0.24 (0.08, 0.40) | 0.003 |
| Mode of delivery | ||||
| Non-labour caesarean section | Reference | Reference | ||
| Intrapartum caesarean section | −0.11 (−0.36, 0.14) | 0.388 | −0.15 (−0.44, 1.35) | 0.299 |
| Vaginal delivery | −0.21 (−0.41, −0.14) | 0.036 | −0.29 (−0.52, −0.06) | 0.013 |
| Timing of placental collection after delivery (minutes) | ||||
| ≤30 | Reference | Reference | ||
| 31–60 | −0.18 (−0.39, 0.03) | 0.094 | −0.18 (−0.41, 0.05) | 0.133 |
| 61–90 | −0.30 (−0.54, −0.06) | 0.013 | −0.29 (−0.55, −0.02) | 0.033 |
| ≥91 | −0.35 (−0.63, −0.07) | 0.013 | −0.22 (−0.53, 0.08) | 0.148 |
| Continuous variable | Unadjusted β (95% CI) Placental inositol SDs/unit increase | P value | Adjusted β (95% CI)a Placental inositol SDs/unit increase | P value |
| 2hPG (mmol/L) | −0.05 (−0.10, −0.01) | 0.021 | −0.06 (−0.12, −0.01) | 0.028 |
| Gestational age at birth (days) | 0.01 (0, 0.02) | 0.026 | 0.01 (0, 0.03) | 0.008 |
2hPG 2-hour plasma glucose.
aAdjusted for maternal age, ethnicity, parity, pre-pregnancy BMI, neonatal sex, and mutually adjusted for tobacco smoke exposure, gestational age, mode of delivery, timing of placental collection after delivery, and 2hPG at mid-gestation.