Table 4.
Adjusted associations between maternal mid-gestation FPG and neonatal abdominal adiposity stratified by placental inositol tertiles.
| FPG (mmol/L) | sSAT (ml) | dSAT (ml) | IAT (ml) | TAAT (ml) | |||||
|---|---|---|---|---|---|---|---|---|---|
| P for interactiona | 0.021 | 0.015 | 0.016 | 0.004 | |||||
| Tertiles of inositol | Inositol z-score, range | βb (95% CI) | P value | βb (95% CI) | P value | βb (95% CI) | P value | βb (95% CI) | P value |
| All in MRI subset | |||||||||
| Lowest (n = 80c) | −3.337, −0.473 | 12.0 (6.2, 17.8) | <0.001 | 3.5 (1.8, 5.3) | <0.001 | 5.4 (3.5, 7.4) | <0.001 | 21.0 (13.1, 28.8) | <0.001 |
| Middle (n = 65c) | −0.469, 0.336 | 12.1 (5.7, 18.5) | 0.004 | 3.3 (1.1, 5.5) | 0.002 | 4.3 (1.4, 7.5) | 0.009 | 19.7 (9.7, 29.7) | <0.001 |
| Highest (n = 74c) | 0.342, 3.610 | 1.6 (−4.9, 8.0) | 0.625 | −0.3 (−2.6, 2.0) | 0.805 | −0.5 (−3.8, 2.9) | 0.770 | 0.8 (−8.4, 10.0) | 0.862 |
| Cases of normoglycaemia with valid MRI datad | |||||||||
| Lowest (n = 64c) | −3.337, −0.473 | 12.5 (4.6, 20.4) | 0.003 | 3.2 (0.6, 5.8) | 0.016 | 5.6 (2.5, 8.6) | 0.001 | 21.3 (10.2, 32.3) | <0.001 |
| Middle (n = 52c) | −0.469, 0.336 | 5.7 (−5.5, 16.9) | 0.307 | 0 (-3.9, 3.9) | 0.997 | −2.1 (−6.8, 2.6) | 0.378 | 3.7 (−13.3, 20.6) | 0.666 |
| Highest (n = 66c) | 0.342, 3.610 | −1.7 (−9.9, 6.5) | 0.685 | −1.4 (−4.4, 1.6) | 0.340 | −2 (−6.4, 2.4) | 0.378 | −5.0 (−16.8, 6.7) | 0.394 |
Adjusted for maternal age, ethnicity, parity, pre-pregnancy BMI, tobacco smoke exposure, gestational age, neonatal sex, birthweight, and age on MRI day.
dSAT deep subcutaneous adipose tissue, FPG fasting plasma glucose, IAT internal adipose tissue, sSAT superficial subcutaneous adipose tissue, TAAT total abdominal adipose tissue (sum of sSAT, dSAT and IAT).
aInteraction between placental inositol tertiles and FPG on neonatal abdominal adiposity with adjustment for covariates among all in the MRI subset.
bBeta (β) represents the change in ml per mmol/L increase in FPG.
cOnly cases with full data sets available are presented.
dDefined as those with normal oral glucose tolerance test by the WHO 1999 criteria.