Table 2.

Unadjusted and adjusted associations between obstructive sleep apnea and severity of acute asthma, according to obesity

Obesity status and outcomes	Obstructive sleep apnea (95% CI)	No obstructive sleep apnea (95% CI)	Unadjusted association 95% CI)	P value	Adjusted association* (95% CI)	P value
Non-obesity (n=55,307)
Non-invasive positive pressure ventilation	12.2% (10.9%-13.7%)	3.0% (2.9%-3.2%)	5.14 (4.42-5.98)	<0.001	4.98 (4.23-5.88)	<0.001
Invasive mechanical ventilation	1.8% (1.3%-2.5%)	2.0% (1.8%-2.1%)	0.97 (0.70-1.35)	0.85	1.09 (0.94-2.13)	0.64
Hospital length-of-stay ≥4 days	61.0% (58.9%-63.1%)	45.9% (45.5%-46.3%)	1.82 (1.66-1.99)	<0.001	1.41 (1.28-1.56)	<0.001
Hospital length-of-stay as a count variable, day, median (IQR)	3 (2-5)	2 (1-4)	1.28 (1.22-1.35)†	<0.001	1.14 (1.08-1.20)†	<0.001
In-hospital mortality	0.14% (0.05%-0.44%)	0.16% (0.13%-0.20%)	0.90 (0.27-2.95)	0.86	0.37 (0.08-1.66)	0.19
Obesity (n=18,101)
Non-invasive positive pressure ventilation	16.0% (15.0%-17.0%)	2.4% (3.1%-3.8%)	5.91 (5.15-6.79)	<0.001	5.49 (4.73-6.36)	<0.001
Invasive mechanical ventilation	1.7% (1.4%-2.1%)	1.4% (1.2%-1.6%)	1.17 (0.91-1.52)	0.23	0.98 (0.72-1.33)	0.91
Hospital length-of-stay ≥4 days	67.9% (66.7%-69.2%)	56.1% (55.2%-56.9%)	1.64 (1.53-1.75)	<0.001	1.40 (1.30-1.51)	<0.001
Hospital length-of-stay as a count variable, day, median (IQR)	3 (2-5)	3 (2-4)	1.25 (1.20-1.30)†	<0.001	1.14 (1.09-1.18)†	<0.001
In-hospital mortality	0.15% (0.07%-0.29%)	0.15% (0.10%-0.24%)	0.97 (0.42-2.25)	0.95	0.50 (0.19-1.36)	0.18

Abbreviations: CI, confidence interval; IQR, interquartile range.

Associations are indicated by odds ratio unless otherwise specified.

^*Logistic regression model for the binomial outcomes and negative binomial model for the count outcome (hospital length-of-stay), adjusting for age, sex, race/ethnicity, primary insurance, household income, residential status, comorbidities, hospital state, and year.

^†Incidence rate ratio.