Figure 8.

Disruptor of telomeric silencing 1-like deficiency restores the innate immune response to ALV-J infection in a time-dependent manner. (A) HD11 cells and DOT1L-KO cells were infected with ALV-J (MOI 2). Cell lysates were prepared at 0, 24, and 48 hpi for western blot to detect the protein expression levels of MDA5, total‐ and phospho-TBK1, STAT1, and β-actin. (B) Relative protein levels were quantified by densitometry using ImageJ software. All the data were shown as mean ± SD (error bars) from three independent experiments. ^**p < 0.01; ^***p < 0.001; unpaired, two-tailed Student’s t-test.