Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 8;11:592514. doi: 10.3389/fneur.2020.592514

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Fei, Shi, Song and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

A summary of energy metabolism patterns in neurons. Glucose and ketone (KET) are recognized as energy substrates, which are labeled as ① and ② respectively. Lactate in the blood can also be utilized as an energy source for the brain during moderate or intense exercise (marked as ③) (20, 29). Glycogen stored in astrocytes generated lactate via glycogenolysis and lactate was then shuttled to neurons (marked as ④) (30). The astrocyte-neuron lactate shuttle is very important in sustaining the energy metabolisms of neurons during high synaptic activity (marked as ⑤) (13). G6P: glucose 6 phosphate, Pyr, pyruvate; PDH, pyruvate dehydrogenase; Ace-CoA, acetyl-coenzyme A.