Table 1.
Baseline characteristics of the LVO study population from INSPIRE and EXTEND-IA.
| INSPIRE | EXTEND-IA RCT | |||
|---|---|---|---|---|
| EVT | No EVT | EVT | No EVT | |
| (N = 178) | (N = 584) | (N = 35) | (N = 35) | |
| Age (mean, SD) | 69.7 (14.76) | 71.9 (13.52) | 68.6 (12.3) | 70.2 (11.8) |
| Male gender (N, %) | 95 (53.4%) | 301 (51.5%) | 17 (49%) | 17 (49%) |
| Baseline NIHSS (median, IQR) | 16 (11–21) | 15 (10–18) | 17 (13–20) | 13 (9–19) |
| Baseline core volume (median, IQR) | 18 (7–36) | 18 (7–40) | 12 (4–32) | 18 (4–29) |
| Perfusion lesion volume (median, IQR) | 112 (74–151) | 83 (49–133) | 106 (76–137) | 115 (72–158) |
| Treatment type (N, %) | ||||
| EVT + tPA | 86 (48.3%) | 0 | 35 (100%)* | 0 |
| EVT only | 92 (51.7%) | 0 | 0 | 0 |
| tPA only | 0 | 346 (59.3%) | 0 | 35 (100%) |
| Target mismatch | 156 (87.6%) | 452 (77.4%) | 100% | 100% |
| Core volume ≥70 ml | 11 (6.2%) | 68 (11.6%) | 0% | 0% |
| Median time from onset to hospital arrival | 95 (43–148) | 112 (53–171) | 78 (54–112) | 80 (56–115) |
| Median time from onset to tPA | 156 (120–187) | 171 (127–211) | 127 (93–162) | 145 (105–180) |
| Successful reperfusion (N, %) | 90 (74.4%)** | 242 (53.7%)** | 35 (100%) | 13 (37%) |
| Occlusion site (N, %) | ||||
| ICA | 53 (29.8%) | 151 (25.9%) | 11 (31%) | 11 (31%) |
| M1 | 115 (64.6%) | 310 (53.1%) | 20 (57%) | 18 (51%) |
| M2 | 10 (5.6%) | 123 (21.0%) | 4 (11%) | 6 (17%) |
| Three-month mRS | ||||
| mRS 0 | 27 (15.2%) | 93 (15.9%) | 9 (26%) | 6 (17%) |
| mRS 1 | 39 (21.9%) | 96 (16.4%) | 9 (26%) | 4 (11%) |
| mRS 2 | 19 (10.7%) | 68 (11.6%) | 7 (20%) | 4 (11%) |
| mRS 3 | 41 (23.0%) | 76 (13.0%) | 6 (17%) | 4 (11%) |
| mRS 4 | 15 (8.4%) | 85 (14.6%) | 1 (3%) | 6 (17%) |
| mRS 5 | 8 (4.5%) | 60 (10.3%) | 0 (0%) | 4 (11%) |
| mRS 6 | 29 (16.3%) | 106 (18.2%) | 3 (9%) | 7 (20%) |
Age, gender, baseline NIHSS, volumes of infarct core and perfusion lesion, and occlusion locations are not significantly different for patients who received EVT between INSPIRE and EXTEND-IA participants.
On the basis of intention-to-treat principle;
57 patients in the EVT and 133 patients in the no EVT group did not have the 24-h TICI outcome. The proportion of successful reperfusion was significantly different between the EVT and no EVT groups within INSPIRE (p < 0.0001).
Baseline core volume, perfusion lesion volume, and penumbra volume are expressed in ml.
EVT, endovascular thrombectomy; IQR, interquartile range; SD, standard deviation; ICA, internal carotid artery; tPA, tissue plasminogen activator.