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. 2020 Dec 8;8:601400. doi: 10.3389/fcell.2020.601400

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Copyright © 2020 Wang, Teng, Lei, Ji, Cui, Fu, Lin, Yang, Fan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of AZ-628 in ABCG2-overexpressing drug-selected cancer cells. Sensitization of mitoxantrone resistance by AZ-628 in (A) H460/MX20 and (B) S1-M1-80 cells. Sensitization of SN-38 resistance by AZ-628 in (C) H460/MX20 and (D) S1-M1-80 cells. Sensitization of topotecan resistance by AZ-628 in (E) H460/MX20 and (F) S1-M1-80 cells. Effects of AZ-628 on (G) H460/MX20 and (H) S1-M1-80 cells when incubated with cisplatin. Parental cells (H460 or S1) were used as drug sensitive control cell lines. Columns and error bars represent mean ± SD. Statistical significance (*) was determined by p < 0.05.