TABLE 3.

Main combination therapies targeting the IIGFs and estrogen signaling.

Combination therapies targeting		References or ClinicalTrials.gov identifiers
IIGFs	Estrogens
Figitumumab	Exemestane	Ryan et al., 2011
Ganitumab	Exemestane or fulvestrant	Robertson et al., 2013
Linsitinib	Letrozole	NCT01205685
MEDI-573	Letrozole, anastrozole, or exemestane	NCT01446159